diff --git a/include/boost/config/compiler/clang.hpp b/include/boost/config/compiler/clang.hpp
index d7fd76f9..dd54691c 100644
--- a/include/boost/config/compiler/clang.hpp
+++ b/include/boost/config/compiler/clang.hpp
@@ -52,7 +52,15 @@
 // Clang supports "long long" in all compilation modes.
 #define BOOST_HAS_LONG_LONG
 
-#if defined(__SIZEOF_INT128__)
+//
+// We disable this if the compiler is really nvcc as it
+// doesn't actually support __int128 as of CUDA_VERSION=5000
+// even though it defines __SIZEOF_INT128__.
+// See https://svn.boost.org/trac/boost/ticket/10418
+// Only re-enable this for nvcc if you're absolutely sure
+// of the circumstances under which it's supported:
+//
+#if defined(__SIZEOF_INT128__) && !defined(__CUDACC__)
 #  define BOOST_HAS_INT128
 #endif