diff --git a/Source/Core/DolphinQt/Settings/InterfacePane.cpp b/Source/Core/DolphinQt/Settings/InterfacePane.cpp
index 198d0810e8..603e7a8447 100644
--- a/Source/Core/DolphinQt/Settings/InterfacePane.cpp
+++ b/Source/Core/DolphinQt/Settings/InterfacePane.cpp
@@ -91,7 +91,7 @@ InterfacePane::InterfacePane(QWidget* parent) : QWidget(parent)
   ConnectLayout();
 
   connect(&Settings::Instance(), &Settings::EmulationStateChanged, this,
-          &InterfacePane::LoadConfig);
+          &InterfacePane::UpdateShowDebuggingCheckbox);
 }
 
 void InterfacePane::CreateLayout()
@@ -228,7 +228,8 @@ void InterfacePane::ConnectLayout()
           &Settings::GameListRefreshRequested);
   connect(m_checkbox_use_covers, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
   connect(m_checkbox_disable_screensaver, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
-  connect(m_checkbox_show_debugging_ui, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
+  connect(m_checkbox_show_debugging_ui, &QCheckBox::toggled, &Settings::Instance(),
+          &Settings::SetDebugModeEnabled);
   connect(m_checkbox_focused_hotkeys, &QCheckBox::toggled, this, &InterfacePane::OnSaveConfig);
   connect(m_combobox_theme, &QComboBox::currentIndexChanged, this,
           [this](int index) { Settings::Instance().TriggerThemeChanged(); });
@@ -253,24 +254,39 @@ void InterfacePane::ConnectLayout()
           &Settings::SetLockCursor);
 }
 
-void InterfacePane::LoadConfig()
+void InterfacePane::UpdateShowDebuggingCheckbox()
 {
   SignalBlocking(m_checkbox_show_debugging_ui)
       ->setChecked(Settings::Instance().IsDebugModeEnabled());
 
+  static constexpr char TR_SHOW_DEBUGGING_UI_DESCRIPTION[] = QT_TR_NOOP(
+      "Shows Dolphin's debugging User Interface. This lets you view and modify a game's code and "
+      "memory contents, set debugging breakpoints, examine network requests, and more."
+      "<br><br><dolphin_emphasis>If unsure, leave this unchecked.</dolphin_emphasis>");
+  static constexpr char TR_DISABLED_IN_HARDCORE_DESCRIPTION[] =
+      QT_TR_NOOP("<dolphin_emphasis>Disabled in Hardcore Mode.</dolphin_emphasis>");
+
 #ifdef USE_RETRO_ACHIEVEMENTS
   bool hardcore = AchievementManager::GetInstance().IsHardcoreModeActive();
   SignalBlocking(m_checkbox_show_debugging_ui)->setEnabled(!hardcore);
   if (hardcore)
   {
-    m_checkbox_show_debugging_ui->SetDescription(
-        tr("<dolphin_emphasis>Disabled in Hardcore Mode.</dolphin_emphasis>"));
+    m_checkbox_show_debugging_ui->SetDescription(tr("%1<br><br>%2")
+                                                     .arg(tr(TR_SHOW_DEBUGGING_UI_DESCRIPTION))
+                                                     .arg(tr(TR_DISABLED_IN_HARDCORE_DESCRIPTION)));
   }
   else
   {
-    m_checkbox_show_debugging_ui->SetDescription({});
+    m_checkbox_show_debugging_ui->SetDescription(tr(TR_SHOW_DEBUGGING_UI_DESCRIPTION));
   }
+#else
+  m_checkbox_show_debugging_ui->SetDescription(tr(TR_SHOW_DEBUGGING_UI_DESCRIPTION));
 #endif  // USE_RETRO_ACHIEVEMENTS
+}
+
+void InterfacePane::LoadConfig()
+{
+  UpdateShowDebuggingCheckbox();
 
   const Settings::StyleType style_type = Settings::Instance().GetStyleType();
   const QString userstyle = Settings::Instance().GetUserStyleName();
@@ -306,7 +322,6 @@ void InterfacePane::LoadConfig()
 
 void InterfacePane::OnSaveConfig()
 {
-  Settings::Instance().SetDebugModeEnabled(m_checkbox_show_debugging_ui->isChecked());
   const auto selected_style = m_combobox_userstyle->currentData();
   bool is_builtin_type = false;
   const int style_type_int = selected_style.toInt(&is_builtin_type);
diff --git a/Source/Core/DolphinQt/Settings/InterfacePane.h b/Source/Core/DolphinQt/Settings/InterfacePane.h
index 2cdc9e1ebe..b1d0f11c2d 100644
--- a/Source/Core/DolphinQt/Settings/InterfacePane.h
+++ b/Source/Core/DolphinQt/Settings/InterfacePane.h
@@ -26,6 +26,7 @@ private:
   void CreateInGame();
   void AddDescriptions();
   void ConnectLayout();
+  void UpdateShowDebuggingCheckbox();
   void LoadConfig();
   void OnSaveConfig();
   void OnCursorVisibleMovement();