diff --git a/include/fmt/core.h b/include/fmt/core.h
index 44cc3d95..c2f997f7 100644
--- a/include/fmt/core.h
+++ b/include/fmt/core.h
@@ -266,7 +266,7 @@ template <typename T> struct std_string_view {};
 
 #ifdef FMT_USE_INT128
 // Do nothing.
-#elif defined(__SIZEOF_INT128__)
+#elif defined(__SIZEOF_INT128__) && !FMT_NVCC
 #  define FMT_USE_INT128 1
 using int128_t = __int128_t;
 using uint128_t = __uint128_t;