diff --git a/cmake/FindClang.cmake b/cmake/FindClang.cmake
index 0e1f5db36c6..3176db73b74 100644
--- a/cmake/FindClang.cmake
+++ b/cmake/FindClang.cmake
@@ -12,3 +12,15 @@ if (TARGET clangTooling AND NOT CLANGTOOLING_LINK_CLANG_DYLIB)
 elseif (TARGET clang-cpp)
   set(CLANG_TOOLING_LIBS libclang clang-cpp)
 endif()
+
+SET(QTC_CLANG_BUILDMODE_MATCH ON)
+if (WIN32)
+  string(TOLOWER ${CMAKE_BUILD_TYPE} _type)
+  get_target_property(_llvmConfigs libclang IMPORTED_CONFIGURATIONS)
+  string(TOLOWER ${_llvmConfigs} _llvm_configs)
+  list(FIND _llvm_configs ${_type} _build_type_found)
+  if (_build_type_found LESS 0)
+    set(QTC_CLANG_BUILDMODE_MATCH OFF)
+    message("Build mode mismatch (debug vs release): limiting clangTooling")
+  endif()
+endif()
diff --git a/src/plugins/clangformat/CMakeLists.txt b/src/plugins/clangformat/CMakeLists.txt
index 9e91349a3c3..83593064265 100644
--- a/src/plugins/clangformat/CMakeLists.txt
+++ b/src/plugins/clangformat/CMakeLists.txt
@@ -1,5 +1,5 @@
 add_qtc_plugin(ClangFormat
-  CONDITION TARGET libclang AND LLVM_PACKAGE_VERSION VERSION_GREATER_EQUAL 10.0.0
+  CONDITION TARGET libclang AND LLVM_PACKAGE_VERSION VERSION_GREATER_EQUAL 10.0.0 AND QTC_CLANG_BUILDMODE_MATCH
   DEPENDS Utils Qt5::Widgets clangFormat
   INCLUDES "${CLANG_INCLUDE_DIRS}"
   PLUGIN_DEPENDS Core TextEditor CppEditor CppTools ProjectExplorer
diff --git a/src/plugins/clangpchmanager/CMakeLists.txt b/src/plugins/clangpchmanager/CMakeLists.txt
index c1c9b29f93c..bc637b5640a 100644
--- a/src/plugins/clangpchmanager/CMakeLists.txt
+++ b/src/plugins/clangpchmanager/CMakeLists.txt
@@ -1,6 +1,6 @@
 add_qtc_plugin(ClangPchManager
   BUILD_DEFAULT OFF
-  CONDITION TARGET libclang
+  CONDITION TARGET libclang AND QTC_CLANG_BUILDMODE_MATCH
   DEPENDS ClangSupport CPlusPlus
   DEFINES CLANGPCHMANAGER_LIB
   PLUGIN_DEPENDS Core CppTools
diff --git a/src/plugins/clangrefactoring/CMakeLists.txt b/src/plugins/clangrefactoring/CMakeLists.txt
index 95c926dc2d0..37b3221e451 100644
--- a/src/plugins/clangrefactoring/CMakeLists.txt
+++ b/src/plugins/clangrefactoring/CMakeLists.txt
@@ -1,6 +1,6 @@
 add_qtc_plugin(ClangRefactoring
   BUILD_DEFAULT OFF
-  CONDITION TARGET libclang
+  CONDITION TARGET libclang AND QTC_CLANG_BUILDMODE_MATCH
   DEPENDS ClangSupport CPlusPlus
   PLUGIN_DEPENDS Core CppTools TextEditor ClangPchManager
   SOURCES ${TEST_SOURCES}
diff --git a/tests/unit/unittest/CMakeLists.txt b/tests/unit/unittest/CMakeLists.txt
index e28079d40b8..580e917cd03 100644
--- a/tests/unit/unittest/CMakeLists.txt
+++ b/tests/unit/unittest/CMakeLists.txt
@@ -1,3 +1,8 @@
+if (NOT QTC_CLANG_BUILDMODE_MATCH)
+    message(STATUS "Skipping unittest due to build mode mismatch")
+    return()
+endif()
+
 find_package(Googletest MODULE)
 find_package(GoogleBenchmark MODULE)