diff --git a/src/plugins/mesonprojectmanager/mesonpluginconstants.h b/src/plugins/mesonprojectmanager/mesonpluginconstants.h
index 4329ae987d3..7aff7a7b245 100644
--- a/src/plugins/mesonprojectmanager/mesonpluginconstants.h
+++ b/src/plugins/mesonprojectmanager/mesonpluginconstants.h
@@ -35,6 +35,7 @@ const char ID[] = "MesonProjectManager.MesonProject";
 
 namespace BuildConfiguration {
 const char BUILD_TYPE_KEY[] = "MesonProjectManager.BuildConfig.Type";
+const char PARAMETERS_KEY[] = "MesonProjectManager.BuildConfig.Parameters";
 }
 
 // Settings page
diff --git a/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.cpp b/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.cpp
index 57cd625081e..cd5f4d48011 100644
--- a/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.cpp
+++ b/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.cpp
@@ -55,6 +55,7 @@ MesonBuildSettingsWidget::MesonBuildSettingsWidget(MesonBuildConfiguration *buil
     auto buildDirAspect = buildCfg->buildDirectoryAspect();
     buildDirAspect->addToLayout(buildDirWBuilder);
 
+    ui->parametersLineEdit->setText(buildCfg->parameters());
     ui->optionsFilterLineEdit->setFiltering(true);
 
     ui->optionsTreeView->sortByColumn(0, Qt::AscendingOrder);
@@ -137,6 +138,9 @@ MesonBuildSettingsWidget::MesonBuildSettingsWidget(MesonBuildConfiguration *buil
         m_showProgressTimer.start();
         bs->wipe();
     });
+    connect(ui->parametersLineEdit, &QLineEdit::editingFinished, this, [this, buildCfg] {
+        buildCfg->setParameters(ui->parametersLineEdit->text());
+    });
     bs->triggerParsing();
 }
 
diff --git a/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.ui b/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.ui
index bedfa074fed..214101daaae 100644
--- a/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.ui
+++ b/src/plugins/mesonprojectmanager/project/buildoptions/mesonbuildsettingswidget.ui
@@ -83,6 +83,20 @@ Useful if build directory is corrupted or when rebuilding with a newer version o
        <property name="bottomMargin">
         <number>0</number>
        </property>
+       <item>
+        <layout class="QHBoxLayout" name="horizontalLayout">
+         <item>
+          <widget class="QLabel" name="label">
+           <property name="text">
+            <string>Parameters</string>
+           </property>
+          </widget>
+         </item>
+         <item>
+          <widget class="QLineEdit" name="parametersLineEdit"/>
+         </item>
+        </layout>
+       </item>
        <item>
         <widget class="QWidget" name="buildDirWidget" native="true"/>
        </item>
diff --git a/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.cpp b/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.cpp
index 4334e431dc3..9159c7de657 100644
--- a/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.cpp
+++ b/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.cpp
@@ -42,6 +42,7 @@
 #include <projectexplorer/projectmacroexpander.h>
 
 #include <utils/fileutils.h>
+#include <utils/qtcprocess.h>
 
 #include <QDir>
 
@@ -117,10 +118,27 @@ void MesonBuildConfiguration::build(const QString &target)
         mesonBuildStep->setBuildTarget(originalBuildTarget);
 }
 
+QStringList MesonBuildConfiguration::mesonConfigArgs()
+{
+    return Utils::QtcProcess::splitArgs(m_parameters) + QStringList{QString("-Dbuildtype=%1").arg(mesonBuildTypeName(m_buildType))};
+}
+
+const QString &MesonBuildConfiguration::parameters() const
+{
+    return m_parameters;
+}
+
+void MesonBuildConfiguration::setParameters(const QString &params)
+{
+    m_parameters = params;
+    emit parametersChanged();
+}
+
 QVariantMap MesonBuildConfiguration::toMap() const
 {
     auto data = ProjectExplorer::BuildConfiguration::toMap();
     data[Constants::BuildConfiguration::BUILD_TYPE_KEY] = mesonBuildTypeName(m_buildType);
+    data[Constants::BuildConfiguration::PARAMETERS_KEY] = m_parameters;
     return data;
 }
 
@@ -130,6 +148,7 @@ bool MesonBuildConfiguration::fromMap(const QVariantMap &map)
     m_buildSystem = new MesonBuildSystem{this};
     m_buildType = mesonBuildType(
         map.value(Constants::BuildConfiguration::BUILD_TYPE_KEY).toString());
+    m_parameters = map.value(Constants::BuildConfiguration::PARAMETERS_KEY).toString();
     return res;
 }
 
diff --git a/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.h b/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.h
index 3b1f9075cd8..509d0bea090 100644
--- a/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.h
+++ b/src/plugins/mesonprojectmanager/project/mesonbuildconfiguration.h
@@ -107,10 +107,13 @@ public:
     ProjectExplorer::BuildSystem *buildSystem() const final;
     void build(const QString &target);
 
-    QStringList mesonConfigArgs()
-    {
-        return {QString("-Dbuildtype=%1").arg(mesonBuildTypeName(m_buildType))};
-    }
+    QStringList mesonConfigArgs();
+
+    const QString &parameters() const;
+    void setParameters(const QString &params);
+
+signals:
+    void parametersChanged();
 
 private:
     QVariantMap toMap() const override;
@@ -118,6 +121,7 @@ private:
     MesonBuildType m_buildType;
     ProjectExplorer::NamedWidget *createConfigWidget() final;
     MesonBuildSystem *m_buildSystem = nullptr;
+    QString m_parameters;
 };
 
 class MesonBuildConfigurationFactory final : public ProjectExplorer::BuildConfigurationFactory
diff --git a/src/plugins/mesonprojectmanager/project/mesonbuildsystem.cpp b/src/plugins/mesonprojectmanager/project/mesonbuildsystem.cpp
index b56d96aa870..3506e935389 100644
--- a/src/plugins/mesonprojectmanager/project/mesonbuildsystem.cpp
+++ b/src/plugins/mesonprojectmanager/project/mesonbuildsystem.cpp
@@ -117,7 +117,8 @@ ProjectExplorer::Kit *MesonBuildSystem::MesonBuildSystem::kit()
 
 QStringList MesonBuildSystem::configArgs(bool isSetup)
 {
-    if (!isSetup)
+    const QString &params = mesonBuildConfiguration()->parameters();
+    if (!isSetup || params.contains("--cross-file") || params.contains("--native-file"))
         return m_pendingConfigArgs + mesonBuildConfiguration()->mesonConfigArgs();
     else {
         return QStringList{
@@ -179,6 +180,10 @@ void MesonBuildSystem::init()
         updateKit(kit());
         this->triggerParsing();
     });
+    connect(mesonBuildConfiguration(), &MesonBuildConfiguration::parametersChanged, this, [this]() {
+        updateKit(kit());
+        wipe();
+    });
     connect(mesonBuildConfiguration(), &MesonBuildConfiguration::environmentChanged, this, [this]() {
         m_parser.setEnvironment(buildConfiguration()->environment());
     });