diff --git a/src/plugins/projectexplorer/runconfigurationaspects.cpp b/src/plugins/projectexplorer/runconfigurationaspects.cpp
index 32ab75ee0f9..a794680f445 100644
--- a/src/plugins/projectexplorer/runconfigurationaspects.cpp
+++ b/src/plugins/projectexplorer/runconfigurationaspects.cpp
@@ -806,7 +806,14 @@ void InterpreterAspect::setDefaultInterpreter(const Interpreter &interpreter)
 
 void InterpreterAspect::setCurrentInterpreter(const Interpreter &interpreter)
 {
-    m_currentId = interpreter.id;
+    if (m_comboBox) {
+        const int index = m_interpreters.indexOf(interpreter);
+        if (index < 0 || index >= m_comboBox->count())
+            return;
+        m_comboBox->setCurrentIndex(index);
+    } else {
+        m_currentId = interpreter.id;
+    }
     emit changed();
 }
 
@@ -853,13 +860,12 @@ void InterpreterAspect::updateComboBox()
 {
     int currentIndex = -1;
     int defaultIndex = -1;
-    const QString currentId = m_currentId;
     m_comboBox->clear();
     for (const Interpreter &interpreter : std::as_const(m_interpreters)) {
         int index = m_comboBox->count();
         m_comboBox->addItem(interpreter.name);
         m_comboBox->setItemData(index, interpreter.command.toUserOutput(), Qt::ToolTipRole);
-        if (interpreter.id == currentId)
+        if (interpreter.id == m_currentId)
             currentIndex = index;
         if (interpreter.id == m_defaultId)
             defaultIndex = index;
diff --git a/src/plugins/python/pyside.cpp b/src/plugins/python/pyside.cpp
index 1ca0a9be650..592addd3085 100644
--- a/src/plugins/python/pyside.cpp
+++ b/src/plugins/python/pyside.cpp
@@ -4,9 +4,7 @@
 #include "pyside.h"
 
 #include "pipsupport.h"
-#include "pythonconstants.h"
 #include "pythonplugin.h"
-#include "pythonproject.h"
 #include "pythonsettings.h"
 #include "pythontr.h"
 #include "pythonutils.h"
@@ -116,35 +114,6 @@ void PySideInstaller::handlePySideMissing(const FilePath &python,
     const QString installTooltip = Tr::tr("Install %1 for %2 using pip package installer.")
                                        .arg(pySide, python.toUserOutput());
     info.addCustomButton(Tr::tr("Install"), installCallback, installTooltip);
-
-    if (PythonProject *project = pythonProjectForFile(document->filePath())) {
-        if (ProjectExplorer::Target *target = project->activeTarget()) {
-            auto runConfiguration = target->activeRunConfiguration();
-            if (runConfiguration->id() == Constants::C_PYTHONRUNCONFIGURATION_ID) {
-                const QList<InfoBarEntry::ComboInfo> interpreters = Utils::transform(
-                    PythonSettings::interpreters(), [](const Interpreter &interpreter) {
-                        return InfoBarEntry::ComboInfo{interpreter.name, interpreter.id};
-                    });
-                auto interpreterChangeCallback =
-                    [=, rc = QPointer<RunConfiguration>(runConfiguration)](
-                        const InfoBarEntry::ComboInfo &info) {
-                        changeInterpreter(info.data.toString(), rc);
-                    };
-
-                auto interpreterAspect = runConfiguration->aspect<InterpreterAspect>();
-                QTC_ASSERT(interpreterAspect, return);
-                const QString id = interpreterAspect->currentInterpreter().id;
-                const auto isCurrentInterpreter = Utils::equal(&InfoBarEntry::ComboInfo::data,
-                                                               QVariant(id));
-                const QString switchTooltip = Tr::tr("Switch the Python interpreter for %1")
-                                                  .arg(runConfiguration->displayName());
-                info.setComboInfo(interpreters,
-                                  interpreterChangeCallback,
-                                  switchTooltip,
-                                  Utils::indexOf(interpreters, isCurrentInterpreter));
-            }
-        }
-    }
     document->infoBar()->addInfo(info);
 }
 
diff --git a/src/plugins/python/pythoneditor.cpp b/src/plugins/python/pythoneditor.cpp
index a880272ca76..77768eae359 100644
--- a/src/plugins/python/pythoneditor.cpp
+++ b/src/plugins/python/pythoneditor.cpp
@@ -14,13 +14,23 @@
 
 #include <coreplugin/actionmanager/actionmanager.h>
 #include <coreplugin/actionmanager/commandbutton.h>
+#include <coreplugin/icore.h>
+
+#include <projectexplorer/project.h>
+#include <projectexplorer/projectexplorer.h>
+#include <projectexplorer/session.h>
+#include <projectexplorer/target.h>
 
 #include <texteditor/textdocument.h>
 #include <texteditor/texteditoractionhandler.h>
 
 #include <QAction>
+#include <QActionGroup>
+#include <QComboBox>
 #include <QMenu>
 
+using namespace ProjectExplorer;
+using namespace TextEditor;
 using namespace Utils;
 
 namespace Python::Internal {
@@ -60,30 +70,11 @@ static void registerReplAction(QObject *parent)
                                         Constants::PYTHON_OPEN_REPL_IMPORT_TOPLEVEL);
 }
 
-static QWidget *createEditorWidget()
-{
-    auto widget = new TextEditor::TextEditorWidget;
-    auto replButton = new QToolButton(widget);
-    replButton->setProperty("noArrow", true);
-    replButton->setText(Tr::tr("REPL"));
-    replButton->setPopupMode(QToolButton::InstantPopup);
-    replButton->setToolTip(Tr::tr("Open interactive Python. Either importing nothing, "
-          "importing the current file, or importing everything (*) from the current file."));
-    auto menu = new QMenu(replButton);
-    replButton->setMenu(menu);
-    menu->addAction(Core::ActionManager::command(Constants::PYTHON_OPEN_REPL)->action());
-    menu->addSeparator();
-    menu->addAction(Core::ActionManager::command(Constants::PYTHON_OPEN_REPL_IMPORT)->action());
-    menu->addAction(
-        Core::ActionManager::command(Constants::PYTHON_OPEN_REPL_IMPORT_TOPLEVEL)->action());
-    widget->insertExtraToolBarWidget(TextEditor::TextEditorWidget::Left, replButton);
-    return widget;
-}
-
-class PythonDocument : public TextEditor::TextDocument
+class PythonDocument : public TextDocument
 {
+    Q_OBJECT
 public:
-    PythonDocument() : TextEditor::TextDocument(Constants::C_PYTHONEDITOR_ID)
+    PythonDocument() : TextDocument(Constants::C_PYTHONEDITOR_ID)
     {
         connect(PythonSettings::instance(),
                 &PythonSettings::pylsEnabledChanged,
@@ -110,6 +101,149 @@ public:
     }
 };
 
+class PythonEditorWidget : public TextEditorWidget
+{
+public:
+    PythonEditorWidget(QWidget *parent = nullptr);
+
+protected:
+    void finalizeInitialization() override;
+    void setUserDefinedPython(const Interpreter &interpreter);
+    void updateInterpretersSelector();
+
+private:
+    QToolButton *m_interpreters = nullptr;
+    QList<QMetaObject::Connection> m_projectConnections;
+};
+
+PythonEditorWidget::PythonEditorWidget(QWidget *parent) : TextEditorWidget(parent)
+{
+    auto replButton = new QToolButton(this);
+    replButton->setProperty("noArrow", true);
+    replButton->setText(Tr::tr("REPL"));
+    replButton->setPopupMode(QToolButton::InstantPopup);
+    replButton->setToolTip(Tr::tr("Open interactive Python. Either importing nothing, "
+                                  "importing the current file, "
+                                  "or importing everything (*) from the current file."));
+    auto menu = new QMenu(replButton);
+    replButton->setMenu(menu);
+    menu->addAction(Core::ActionManager::command(Constants::PYTHON_OPEN_REPL)->action());
+    menu->addSeparator();
+    menu->addAction(Core::ActionManager::command(Constants::PYTHON_OPEN_REPL_IMPORT)->action());
+    menu->addAction(
+        Core::ActionManager::command(Constants::PYTHON_OPEN_REPL_IMPORT_TOPLEVEL)->action());
+    insertExtraToolBarWidget(TextEditorWidget::Left, replButton);
+}
+
+void PythonEditorWidget::finalizeInitialization()
+{
+    connect(textDocument(), &TextDocument::filePathChanged,
+            this, &PythonEditorWidget::updateInterpretersSelector);
+    connect(PythonSettings::instance(), &PythonSettings::interpretersChanged,
+            this, &PythonEditorWidget::updateInterpretersSelector);
+    connect(ProjectExplorerPlugin::instance(), &ProjectExplorerPlugin::fileListChanged,
+            this, &PythonEditorWidget::updateInterpretersSelector);
+}
+
+void PythonEditorWidget::setUserDefinedPython(const Interpreter &interpreter)
+{
+    const auto pythonDocument = qobject_cast<PythonDocument *>(textDocument());
+    QTC_ASSERT(pythonDocument, return);
+    FilePath documentPath = pythonDocument->filePath();
+    QTC_ASSERT(!documentPath.isEmpty(), return);
+    if (Project *project = SessionManager::projectForFile(documentPath)) {
+        if (Target *target = project->activeTarget()) {
+            if (RunConfiguration *rc = target->activeRunConfiguration()) {
+                if (auto interpretersAspect= rc->aspect<InterpreterAspect>()) {
+                    interpretersAspect->setCurrentInterpreter(interpreter);
+                    return;
+                }
+            }
+        }
+    }
+    definePythonForDocument(textDocument()->filePath(), interpreter.command);
+    pythonDocument->checkForPyls();
+}
+
+void PythonEditorWidget::updateInterpretersSelector()
+{
+    if (!m_interpreters) {
+        m_interpreters = new QToolButton(this);
+        insertExtraToolBarWidget(TextEditorWidget::Left, m_interpreters);
+        m_interpreters->setMenu(new QMenu(m_interpreters));
+        m_interpreters->setPopupMode(QToolButton::InstantPopup);
+        m_interpreters->setToolButtonStyle(Qt::ToolButtonTextOnly);
+        m_interpreters->setProperty("noArrow", true);
+    }
+
+    QMenu *menu = m_interpreters->menu();
+    QTC_ASSERT(menu, return);
+    menu->clear();
+    for (const QMetaObject::Connection &connection : m_projectConnections)
+        disconnect(connection);
+    m_projectConnections.clear();
+    const FilePath documentPath = textDocument()->filePath();
+    if (Project *project = SessionManager::projectForFile(documentPath)) {
+        m_projectConnections << connect(project,
+                                        &Project::activeTargetChanged,
+                                        this,
+                                        &PythonEditorWidget::updateInterpretersSelector);
+        if (Target *target = project->activeTarget()) {
+            m_projectConnections << connect(target,
+                                            &Target::activeRunConfigurationChanged,
+                                            this,
+                                            &PythonEditorWidget::updateInterpretersSelector);
+            if (RunConfiguration *rc = target->activeRunConfiguration()) {
+                if (auto interpreterAspect = rc->aspect<InterpreterAspect>()) {
+                    m_projectConnections << connect(interpreterAspect,
+                                                    &InterpreterAspect::changed,
+                                                    this,
+                                                    &PythonEditorWidget::updateInterpretersSelector);
+                }
+            }
+        }
+    }
+
+    auto setButtonText = [this](QString text) {
+        constexpr int maxTextLength = 25;
+        if (text.size() > maxTextLength)
+            text = text.left(maxTextLength - 3) + "...";
+        m_interpreters->setText(text);
+    };
+
+    const FilePath currentInterpreter = detectPython(textDocument()->filePath());
+    const QList<Interpreter> configuredInterpreters = PythonSettings::interpreters();
+    bool foundCurrentInterpreter = false;
+    auto interpretersGroup = new QActionGroup(menu);
+    interpretersGroup->setExclusive(true);
+    for (const Interpreter &interpreter : configuredInterpreters) {
+        QAction *action = interpretersGroup->addAction(interpreter.name);
+        connect(action, &QAction::triggered, this, [this, interpreter]() {
+            setUserDefinedPython(interpreter);
+        });
+        action->setCheckable(true);
+        if (!foundCurrentInterpreter && interpreter.command == currentInterpreter) {
+            foundCurrentInterpreter = true;
+            action->setChecked(true);
+            setButtonText(interpreter.name);
+            m_interpreters->setToolTip(interpreter.command.toUserOutput());
+        }
+    }
+    menu->addActions(interpretersGroup->actions());
+    if (!foundCurrentInterpreter) {
+        if (currentInterpreter.exists())
+            setButtonText(currentInterpreter.toUserOutput());
+        else
+            setButtonText(Tr::tr("No Python Selected"));
+    }
+    if (!interpretersGroup->actions().isEmpty())
+       menu->addSeparator();
+    auto settingsAction = menu->addAction(Tr::tr("Manage Python Interpreters"));
+    connect(settingsAction, &QAction::triggered, this, []() {
+        Core::ICore::showOptionsDialog(Constants::C_PYTHONOPTIONS_PAGE_ID);
+    });
+}
+
 PythonEditorFactory::PythonEditorFactory()
 {
     registerReplAction(this);
@@ -119,13 +253,13 @@ PythonEditorFactory::PythonEditorFactory()
         QCoreApplication::translate("OpenWith::Editors", Constants::C_EDITOR_DISPLAY_NAME));
     addMimeType(Constants::C_PY_MIMETYPE);
 
-    setEditorActionHandlers(TextEditor::TextEditorActionHandler::Format
-                            | TextEditor::TextEditorActionHandler::UnCommentSelection
-                            | TextEditor::TextEditorActionHandler::UnCollapseAll
-                            | TextEditor::TextEditorActionHandler::FollowSymbolUnderCursor);
+    setEditorActionHandlers(TextEditorActionHandler::Format
+                            | TextEditorActionHandler::UnCommentSelection
+                            | TextEditorActionHandler::UnCollapseAll
+                            | TextEditorActionHandler::FollowSymbolUnderCursor);
 
     setDocumentCreator([]() { return new PythonDocument; });
-    setEditorWidgetCreator(createEditorWidget);
+    setEditorWidgetCreator([]() { return new PythonEditorWidget; });
     setIndenterCreator([](QTextDocument *doc) { return new PythonIndenter(doc); });
     setSyntaxHighlighterCreator([] { return new PythonHighlighter; });
     setCommentDefinition(CommentDefinition::HashStyle);
@@ -134,3 +268,5 @@ PythonEditorFactory::PythonEditorFactory()
 }
 
 } // Python::Internal
+
+#include "pythoneditor.moc"
diff --git a/src/plugins/python/pythonutils.cpp b/src/plugins/python/pythonutils.cpp
index 24d8a1f1880..346c42d183d 100644
--- a/src/plugins/python/pythonutils.cpp
+++ b/src/plugins/python/pythonutils.cpp
@@ -22,6 +22,12 @@ using namespace Utils;
 
 namespace Python::Internal {
 
+static QHash<FilePath, FilePath> &userDefinedPythonsForDocument()
+{
+    static QHash<FilePath, FilePath> userDefines;
+    return userDefines;
+}
+
 FilePath detectPython(const FilePath &documentPath)
 {
     Project *project = documentPath.isEmpty() ? nullptr
@@ -42,6 +48,10 @@ FilePath detectPython(const FilePath &documentPath)
         }
     }
 
+    const FilePath userDefined = userDefinedPythonsForDocument().value(documentPath);
+    if (userDefined.exists())
+        return userDefined;
+
     // check whether this file is inside a python virtual environment
     const QList<Interpreter> venvInterpreters = PythonSettings::detectPythonVenvs(documentPath);
     if (!venvInterpreters.isEmpty())
@@ -71,6 +81,11 @@ FilePath detectPython(const FilePath &documentPath)
     return PythonSettings::interpreters().value(0).command;
 }
 
+void definePythonForDocument(const FilePath &documentPath, const FilePath &python)
+{
+    userDefinedPythonsForDocument()[documentPath] = python;
+}
+
 static QStringList replImportArgs(const FilePath &pythonFile, ReplType type)
 {
     using MimeTypes = QList<MimeType>;
diff --git a/src/plugins/python/pythonutils.h b/src/plugins/python/pythonutils.h
index c8adb308ed1..8d5b06974ef 100644
--- a/src/plugins/python/pythonutils.h
+++ b/src/plugins/python/pythonutils.h
@@ -10,6 +10,7 @@ namespace Python::Internal {
 enum class ReplType { Unmodified, Import, ImportToplevel };
 void openPythonRepl(QObject *parent, const Utils::FilePath &file, ReplType type);
 Utils::FilePath detectPython(const Utils::FilePath &documentPath);
+void definePythonForDocument(const Utils::FilePath &documentPath, const Utils::FilePath &python);
 QString pythonName(const Utils::FilePath &pythonPath);
 
 class PythonProject;