diff --git a/src/plugins/ios/iosrunfactories.cpp b/src/plugins/ios/iosrunfactories.cpp
index e9c82197842..c4ad3fcafea 100644
--- a/src/plugins/ios/iosrunfactories.cpp
+++ b/src/plugins/ios/iosrunfactories.cpp
@@ -157,7 +157,26 @@ bool IosRunControlFactory::canRun(RunConfiguration *runConfiguration,
 {
     if (mode != NormalRunMode && mode != DebugRunMode)
         return false;
-    return qobject_cast<IosRunConfiguration *>(runConfiguration);
+    IosRunConfiguration *rc = qobject_cast<IosRunConfiguration *>(runConfiguration);
+    if (!rc)
+        return false;
+
+    IDevice::ConstPtr device = DeviceKitInformation::device(rc->target()->kit());
+    if (!device || device->deviceState() != IDevice::DeviceReadyToUse)
+        return false;
+
+    // The device can only run the same application once, any subsequent runs will
+    // not launch a second instance. Disable the Run button if the application is already
+    // running on the device.
+    if (m_activeRunControls.contains(device->id())) {
+        QPointer<ProjectExplorer::RunControl> activeRunControl = m_activeRunControls[device->id()];
+        if (activeRunControl && activeRunControl.data()->isRunning())
+            return false;
+        else
+            m_activeRunControls.remove(device->id());
+    }
+
+    return rc;
 }
 
 RunControl *IosRunControlFactory::create(RunConfiguration *runConfig,
@@ -166,10 +185,15 @@ RunControl *IosRunControlFactory::create(RunConfiguration *runConfig,
     Q_ASSERT(canRun(runConfig, mode));
     IosRunConfiguration *rc = qobject_cast<IosRunConfiguration *>(runConfig);
     Q_ASSERT(rc);
+    RunControl *res = 0;
     if (mode == NormalRunMode)
-        return new Ios::Internal::IosRunControl(rc);
+        res = new Ios::Internal::IosRunControl(rc);
     else
-        return IosDebugSupport::createDebugRunControl(rc, errorMessage);
+        res = IosDebugSupport::createDebugRunControl(rc, errorMessage);
+    IDevice::ConstPtr device = DeviceKitInformation::device(rc->target()->kit());
+    if (device)
+        m_activeRunControls[device->id()] = res;
+    return res;
 }
 
 } // namespace Internal
diff --git a/src/plugins/ios/iosrunfactories.h b/src/plugins/ios/iosrunfactories.h
index 8f4641c331c..bf6272fea91 100644
--- a/src/plugins/ios/iosrunfactories.h
+++ b/src/plugins/ios/iosrunfactories.h
@@ -83,6 +83,8 @@ public:
     ProjectExplorer::RunControl *create(ProjectExplorer::RunConfiguration *runConfiguration,
                        ProjectExplorer::RunMode mode,
                        QString *errorMessage) QTC_OVERRIDE;
+private:
+    mutable QMap<Core::Id, QPointer<ProjectExplorer::RunControl> > m_activeRunControls;
 };
 
 } // namespace Internal