diff --git a/README.md b/README.md
index 14a08075fc2..96da4ba0e5a 100644
--- a/README.md
+++ b/README.md
@@ -40,16 +40,16 @@ https://doc.qt.io/qtcreator-extending/coding-style.html
 
 Prerequisites:
 
-* Qt 6.4.3 or later. The Qt version that you use to build Qt Creator defines the
+* Qt 6.5.3 or later. The Qt version that you use to build Qt Creator defines the
   minimum platform versions that the result supports
-  (Windows 10, RHEL/CentOS 8.4, Ubuntu 20.04, macOS 10.15 for Qt 6.4.3).
+  (Windows 10, RHEL/CentOS 8.8, Ubuntu 22.04, macOS 11 for Qt 6.5.3).
 * Qt WebEngine module for QtWebEngine based help viewer
 * On Windows:
     * MinGW with GCC 11.2 or Visual Studio 2019 or later
     * Python 3.8 or later (optional, needed for the python enabled debug helper)
     * Debugging Tools for Windows (optional, for MSVC debugging support with CDB)
 * On macOS: latest Xcode
-* On Linux: GCC 9 or later
+* On Linux: GCC 10 or later
 * LLVM/Clang 14 or later (optional, LLVM/Clang 17 is recommended.
   See [instructions](#getting-llvmclang-for-the-clang-code-model) on how to
   get LLVM.
diff --git a/cmake/QtCreatorAPI.cmake b/cmake/QtCreatorAPI.cmake
index e05a48563bc..e213eb73ce0 100644
--- a/cmake/QtCreatorAPI.cmake
+++ b/cmake/QtCreatorAPI.cmake
@@ -3,7 +3,7 @@ if(QT_CREATOR_API_DEFINED)
 endif()
 set(QT_CREATOR_API_DEFINED TRUE)
 
-set(IDE_QT_VERSION_MIN "6.4.3")
+set(IDE_QT_VERSION_MIN "6.5.3")
 
 include(${CMAKE_CURRENT_LIST_DIR}/QtCreatorAPIInternal.cmake)
 include(${CMAKE_CURRENT_LIST_DIR}/QtcSeparateDebugInfo.cmake)
diff --git a/cmake/QtCreatorAPIInternal.cmake b/cmake/QtCreatorAPIInternal.cmake
index ef7b55ff830..2d1b104c2c7 100644
--- a/cmake/QtCreatorAPIInternal.cmake
+++ b/cmake/QtCreatorAPIInternal.cmake
@@ -22,9 +22,7 @@ list(APPEND DEFAULT_DEFINES
   QT_CREATOR
   QT_NO_JAVA_STYLE_ITERATORS
   QT_NO_CAST_TO_ASCII QT_RESTRICTED_CAST_FROM_ASCII QT_NO_FOREACH
-  QT_DISABLE_DEPRECATED_BEFORE=0x050900
   QT_DISABLE_DEPRECATED_UP_TO=0x050900
-  QT_WARN_DEPRECATED_BEFORE=0x060400
   QT_WARN_DEPRECATED_UP_TO=0x060400
   QT_USE_QSTRINGBUILDER
 )
diff --git a/coin/instructions/common_environment.yaml b/coin/instructions/common_environment.yaml
index dedcbaf2fc5..b36a480a57d 100644
--- a/coin/instructions/common_environment.yaml
+++ b/coin/instructions/common_environment.yaml
@@ -20,7 +20,7 @@ instructions:
         instructions:
           - type: EnvironmentVariable
             variableName: QTC_QT_BASE_URL
-            variableValue: "https://ci-files02-hki.ci.qt.io/packages/jenkins/qt/6.4.3/release_content/"
+            variableValue: "https://ci-files02-hki.ci.qt.io/packages/jenkins/qt/6.5.3/release_content/"
           - type: EnvironmentVariable
             variableName: MACOSX_DEPLOYMENT_TARGET
             variableValue: 11.0
diff --git a/src/app/main.cpp b/src/app/main.cpp
index 42b28ea500c..e993b4609be 100644
--- a/src/app/main.cpp
+++ b/src/app/main.cpp
@@ -485,8 +485,7 @@ private:
             // Show some kind of GUI with collected messages before exiting.
             // For Windows, Qt already uses a dialog.
             if (HostOsInfo::isLinuxHost()) {
-#if (QT_VERSION >= QT_VERSION_CHECK(6, 5, 0) && QT_VERSION < QT_VERSION_CHECK(6, 5, 3)) \
-    || (QT_VERSION >= QT_VERSION_CHECK(6, 6, 0) && QT_VERSION < QT_VERSION_CHECK(6, 6, 1))
+#if (QT_VERSION >= QT_VERSION_CHECK(6, 6, 0) && QT_VERSION < QT_VERSION_CHECK(6, 6, 1))
                 // Information about potentially missing libxcb-cursor0 is printed by Qt since Qt 6.5.3 and Qt 6.6.1
                 // Add it manually for other versions >= 6.5.0
                 instance->messages.prepend("From 6.5.0, xcb-cursor0 or libxcb-cursor0 is needed to "
diff --git a/src/libs/utils/async.h b/src/libs/utils/async.h
index 4643ea161bb..76e4f01aa40 100644
--- a/src/libs/utils/async.h
+++ b/src/libs/utils/async.h
@@ -171,12 +171,7 @@ public:
 
     QFuture<ResultType> future() const { return m_watcher.future(); }
     ResultType result() const { return m_watcher.result(); }
-#if QT_VERSION > QT_VERSION_CHECK(6, 5, 2)
-    // takeResult is buggy before QTBUG-112513 as it resets the future state to "NoState".
-    // This in turn causes the FutureSynchronizer to deadlock in "waitForFinished", as the
-    // future is not in the finished state anymore.
     ResultType takeResult() const { return m_watcher.future().takeResult(); }
-#endif
     ResultType resultAt(int index) const { return m_watcher.resultAt(index); }
     QList<ResultType> results() const { return future().results(); }
     bool isResultAvailable() const { return future().resultCount(); }
diff --git a/src/libs/utils/persistentsettings.cpp b/src/libs/utils/persistentsettings.cpp
index 2b65aa0ce58..90454ca0dd1 100644
--- a/src/libs/utils/persistentsettings.cpp
+++ b/src/libs/utils/persistentsettings.cpp
@@ -330,11 +330,7 @@ FilePath PersistentSettingsReader::filePath()
     \sa Utils::PersistentSettingsReader
 */
 
-#if QT_VERSION < QT_VERSION_CHECK(6, 5, 0)
 static QString xmlAttrFromKey(const QString &key) { return key; }
-#else
-static QString xmlAttrFromKey(const QString &key) { return key; }
-#endif
 
 static void writeVariantValue(QXmlStreamWriter &w, const QVariant &variant, const QString &key = {})
 {
diff --git a/src/plugins/terminal/shortcutmap.cpp b/src/plugins/terminal/shortcutmap.cpp
index 4e17f0c35e4..31dd9ba604b 100644
--- a/src/plugins/terminal/shortcutmap.cpp
+++ b/src/plugins/terminal/shortcutmap.cpp
@@ -237,11 +237,7 @@ bool ShortcutMap::tryShortcut(QKeyEvent *e)
         return dispatchEvent(e);
     }
     }
-#if QT_VERSION >= QT_VERSION_CHECK(6, 5, 0)
     Q_UNREACHABLE_RETURN(false);
-#else
-    return false;
-#endif
 }
 
 /*! \internal