diff --git a/homeassistant/block_async_io.py b/homeassistant/block_async_io.py
index a8770c7e9c4..090afed822d 100644
--- a/homeassistant/block_async_io.py
+++ b/homeassistant/block_async_io.py
@@ -160,7 +160,7 @@ _BLOCKED_CALLS = BlockedCalls(set())
 def enable() -> None:
     """Enable the detection of blocking calls in the event loop."""
     if _BLOCKED_CALLS.calls:
-        return
+        raise RuntimeError("Blocking call detection is already enabled")
 
     loop_thread_id = threading.get_ident()
     for blocking_call in BLOCKING_CALLS:
diff --git a/tests/test_block_async_io.py b/tests/test_block_async_io.py
index efbc1a69a61..4f9b5a11378 100644
--- a/tests/test_block_async_io.py
+++ b/tests/test_block_async_io.py
@@ -229,6 +229,17 @@ async def test_protect_open(caplog: pytest.LogCaptureFixture) -> None:
     assert "Detected blocking call to open with args" in caplog.text
 
 
+async def test_enable_multiple_times(caplog: pytest.LogCaptureFixture) -> None:
+    """Test trying to enable multiple times."""
+    with patch.object(block_async_io, "_IN_TESTS", False):
+        block_async_io.enable()
+
+    with pytest.raises(
+        RuntimeError, match="Blocking call detection is already enabled"
+    ):
+        block_async_io.enable()
+
+
 @pytest.mark.parametrize(
     "path",
     [