diff --git a/homeassistant/components/zha/manifest.json b/homeassistant/components/zha/manifest.json
index b1511b2f5bb..1c32a9b6149 100644
--- a/homeassistant/components/zha/manifest.json
+++ b/homeassistant/components/zha/manifest.json
@@ -23,7 +23,6 @@
   "requirements": [
     "bellows==0.38.3",
     "pyserial==3.5",
-    "pyserial-asyncio==0.6",
     "zha-quirks==0.0.115",
     "zigpy-deconz==0.23.1",
     "zigpy==0.64.0",
diff --git a/requirements_all.txt b/requirements_all.txt
index 87e4fb9e77d..1e64adc3814 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -2123,7 +2123,6 @@ pysensibo==1.0.36
 pyserial-asyncio-fast==0.11
 
 # homeassistant.components.serial
-# homeassistant.components.zha
 pyserial-asyncio==0.6
 
 # homeassistant.components.acer_projector
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 908792f4069..0b5ccba7f39 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1661,10 +1661,6 @@ pysensibo==1.0.36
 # homeassistant.components.zha
 pyserial-asyncio-fast==0.11
 
-# homeassistant.components.serial
-# homeassistant.components.zha
-pyserial-asyncio==0.6
-
 # homeassistant.components.acer_projector
 # homeassistant.components.crownstone
 # homeassistant.components.usb