diff --git a/homeassistant/components/shelly/__init__.py b/homeassistant/components/shelly/__init__.py
index 5582ab488df5..d12236177b81 100644
--- a/homeassistant/components/shelly/__init__.py
+++ b/homeassistant/components/shelly/__init__.py
@@ -67,6 +67,7 @@ from .utils import (
     get_http_port,
     get_rpc_scripts_event_types,
     get_ws_context,
+    remove_empty_sub_devices,
     remove_stale_blu_trv_devices,
 )
 
@@ -223,6 +224,7 @@ async def _async_setup_block_entry(
         await hass.config_entries.async_forward_entry_setups(
             entry, runtime_data.platforms
         )
+        remove_empty_sub_devices(hass, entry)
     elif (
         sleep_period is None
         or device_entry is None
@@ -334,6 +336,7 @@ async def _async_setup_rpc_entry(hass: HomeAssistant, entry: ShellyConfigEntry)
             hass,
             entry,
         )
+        remove_empty_sub_devices(hass, entry)
     elif (
         sleep_period is None
         or device_entry is None
diff --git a/homeassistant/components/shelly/utils.py b/homeassistant/components/shelly/utils.py
index c814c987621b..075040cb9299 100644
--- a/homeassistant/components/shelly/utils.py
+++ b/homeassistant/components/shelly/utils.py
@@ -884,3 +884,27 @@ def remove_stale_blu_trv_devices(
 
         LOGGER.debug("Removing stale BLU TRV device %s", device.name)
         dev_reg.async_update_device(device.id, remove_config_entry_id=entry.entry_id)
+
+
+@callback
+def remove_empty_sub_devices(hass: HomeAssistant, entry: ConfigEntry) -> None:
+    """Remove sub devices without entities."""
+    dev_reg = dr.async_get(hass)
+    entity_reg = er.async_get(hass)
+
+    devices = dev_reg.devices.get_devices_for_config_entry_id(entry.entry_id)
+
+    for device in devices:
+        if not device.via_device_id:
+            # Device is not a sub-device, skip
+            continue
+
+        if er.async_entries_for_device(entity_reg, device.id, True):
+            # Device has entities, skip
+            continue
+
+        if any(identifier[0] == DOMAIN for identifier in device.identifiers):
+            LOGGER.debug("Removing empty sub-device %s", device.name)
+            dev_reg.async_update_device(
+                device.id, remove_config_entry_id=entry.entry_id
+            )
diff --git a/tests/components/shelly/__init__.py b/tests/components/shelly/__init__.py
index b1c3d1487b4a..69a7e266dcab 100644
--- a/tests/components/shelly/__init__.py
+++ b/tests/components/shelly/__init__.py
@@ -26,7 +26,6 @@ from homeassistant.helpers.device_registry import (
     CONNECTION_NETWORK_MAC,
     DeviceEntry,
     DeviceRegistry,
-    format_mac,
 )
 
 from tests.common import MockConfigEntry, async_fire_time_changed
@@ -152,7 +151,7 @@ def register_device(
     """Register Shelly device."""
     return device_registry.async_get_or_create(
         config_entry_id=config_entry.entry_id,
-        connections={(CONNECTION_NETWORK_MAC, format_mac(MOCK_MAC))},
+        connections={(CONNECTION_NETWORK_MAC, MOCK_MAC)},
     )
 
 
@@ -163,7 +162,7 @@ def register_sub_device(
     return device_registry.async_get_or_create(
         config_entry_id=config_entry.entry_id,
         identifiers={(DOMAIN, f"{MOCK_MAC}-{unique_id}")},
-        via_device=(DOMAIN, format_mac(MOCK_MAC)),
+        via_device=(DOMAIN, MOCK_MAC),
     )
 
 
diff --git a/tests/components/shelly/test_init.py b/tests/components/shelly/test_init.py
index 703df09bb615..8457354351f6 100644
--- a/tests/components/shelly/test_init.py
+++ b/tests/components/shelly/test_init.py
@@ -41,7 +41,7 @@ from homeassistant.helpers.device_registry import DeviceRegistry, format_mac
 from homeassistant.helpers.entity_registry import EntityRegistry
 from homeassistant.setup import async_setup_component
 
-from . import MOCK_MAC, init_integration, mutate_rpc_device_status
+from . import MOCK_MAC, init_integration, mutate_rpc_device_status, register_sub_device
 
 
 async def test_custom_coap_port(
@@ -653,3 +653,30 @@ async def test_blu_trv_stale_device_removal(
 
     assert hass.states.get(trv_201_entity_id) is None
     assert device_registry.async_get(trv_201_entry.device_id) is None
+
+
+async def test_empty_device_removal(
+    hass: HomeAssistant,
+    entity_registry: EntityRegistry,
+    device_registry: DeviceRegistry,
+    mock_rpc_device: Mock,
+) -> None:
+    """Test removal of empty devices due to device configuration changes."""
+    config_entry = await init_integration(hass, 3)
+
+    # create empty sub-device
+    sub_device_entry = register_sub_device(
+        device_registry,
+        config_entry,
+        "boolean:201-boolean",
+    )
+
+    # verify that the sub-device is created
+    assert device_registry.async_get(sub_device_entry.id) is not None
+
+    # device config change triggers a reload
+    await hass.config_entries.async_reload(config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    # verify that the empty sub-device is removed
+    assert device_registry.async_get(sub_device_entry.id) is None