diff --git a/homeassistant/components/nest/media_source.py b/homeassistant/components/nest/media_source.py
index 328a9b000b3..0f26331d7e5 100644
--- a/homeassistant/components/nest/media_source.py
+++ b/homeassistant/components/nest/media_source.py
@@ -64,6 +64,9 @@ async def async_get_media_source(hass: HomeAssistant) -> MediaSource:
 
 async def get_media_source_devices(hass: HomeAssistant) -> Mapping[str, Device]:
     """Return a mapping of device id to eligible Nest event media devices."""
+    if DATA_SUBSCRIBER not in hass.data[DOMAIN]:
+        # Integration unloaded, or is legacy nest integration
+        return {}
     subscriber = hass.data[DOMAIN][DATA_SUBSCRIBER]
     device_manager = await subscriber.async_get_device_manager()
     device_registry = await hass.helpers.device_registry.async_get_registry()
diff --git a/tests/components/nest/test_media_source.py b/tests/components/nest/test_media_source.py
index f52b89c4f4d..95f2afa8a06 100644
--- a/tests/components/nest/test_media_source.py
+++ b/tests/components/nest/test_media_source.py
@@ -16,6 +16,7 @@ from homeassistant.components import media_source
 from homeassistant.components.media_player.errors import BrowseError
 from homeassistant.components.media_source import const
 from homeassistant.components.media_source.error import Unresolvable
+from homeassistant.config_entries import ConfigEntryState
 from homeassistant.helpers import device_registry as dr
 from homeassistant.helpers.template import DATE_STR_FORMAT
 import homeassistant.util.dt as dt_util
@@ -164,6 +165,37 @@ async def test_supported_device(hass, auth):
     assert len(browse.children) == 0
 
 
+async def test_integration_unloaded(hass, auth):
+    """Test the media player loads, but has no devices, when config unloaded."""
+    await async_setup_devices(
+        hass,
+        auth,
+        CAMERA_DEVICE_TYPE,
+        CAMERA_TRAITS,
+    )
+
+    browse = await media_source.async_browse_media(hass, f"{const.URI_SCHEME}{DOMAIN}")
+    assert browse.domain == DOMAIN
+    assert browse.identifier == ""
+    assert browse.title == "Nest"
+    assert len(browse.children) == 1
+
+    entries = hass.config_entries.async_entries(DOMAIN)
+    assert len(entries) == 1
+    entry = entries[0]
+    assert entry.state is ConfigEntryState.LOADED
+
+    assert await hass.config_entries.async_unload(entry.entry_id)
+    assert entry.state == ConfigEntryState.NOT_LOADED
+
+    # No devices returned
+    browse = await media_source.async_browse_media(hass, f"{const.URI_SCHEME}{DOMAIN}")
+    assert browse.domain == DOMAIN
+    assert browse.identifier == ""
+    assert browse.title == "Nest"
+    assert len(browse.children) == 0
+
+
 async def test_camera_event(hass, auth, hass_client):
     """Test a media source and image created for an event."""
     event_timestamp = dt_util.now()